Classical Parkinson disease versus Parkinson complex – Reflections against staging and in favour of heterogeneity
Identifieur interne : 000308 ( Main/Corpus ); précédent : 000307; suivant : 000309Classical Parkinson disease versus Parkinson complex – Reflections against staging and in favour of heterogeneity
Auteurs : G. LinazasoroSource :
- European Journal of Neurology [ 1351-5101 ] ; 2007-07.
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- KwdEn :
Abstract
Pathological studies have prompted the idea that Parkinson disease (PD) is a multisystem disorder, which starts far away from the nigrostriatal dopamine system and it goes through a long pre‐clinical period. Evidence from epidemiological research, functional imaging, olfaction and sleep studies provides support to this hypothesis. Accordingly, PD is seen as an homogeneous disease which sequentially affects different neural structures leading to a well‐defined clinical picture. This concept, recently named PD complex, has deep theoretical and practical implications which raise some concerns. This report shows the concept of classical PD as opposed to PD complex. Although the relevance of the central argument concerning the PD complex concept is admitted, it needs to be fully proved before premature conclusions are drawn. In contrast, the notion of classical and clinically significant PD can explain many of the well‐characterized pathological and clinical features of the disease and it gives support to the idea that the magic word in PD is variability.
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DOI: 10.1111/j.1468-1331.2007.01853.x
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ISTEX:BAC0932AE9102A119D5B8708E49FA434BB2D1D3DLe document en format XML
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Linazasoro, Centro De Investigación Parkinson. Policlínica Gipuzkoa, Parque Tecnológico Miramón, 174, 20009 San Sebastián (Guipúzcoa) Spain (tel./fax: 34 943002818; e‐mail: <email>glinazasoro@terra.es</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE1853.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 29 January 2007 Accepted 23 April 2007</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Classical Parkinson disease versus Parkinson complex – Reflections against staging and in favour of heterogeneity</title><title type="shortAuthors">G. Linazasoro</title><title type="short">Classical Parkinson disease versus Parkinson complex</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>G.</givenNames><familyName>Linazasoro</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="ES"><unparsedAffiliation>Centro De Investigación Parkinson, Policlínica Gipuzkoa, Parque Tecnológico Miramón, San Sebastián (Guipúzcoa), Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">classical Parkinson disease</keyword><keyword xml:id="k2">Parkinson disease</keyword><keyword xml:id="k3">Parkinson disease complex</keyword><keyword xml:id="k4">synucleinopathy</keyword><keyword xml:id="k5">variability</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Pathological studies have prompted the idea that Parkinson disease (PD) is a multisystem disorder, which starts far away from the nigrostriatal dopamine system and it goes through a long pre‐clinical period. Evidence from epidemiological research, functional imaging, olfaction and sleep studies provides support to this hypothesis. Accordingly, PD is seen as an homogeneous disease which sequentially affects different neural structures leading to a well‐defined clinical picture. This concept, recently named PD complex, has deep theoretical and practical implications which raise some concerns. This report shows the concept of classical PD as opposed to PD complex. Although the relevance of the central argument concerning the PD complex concept is admitted, it needs to be fully proved before premature conclusions are drawn. In contrast, the notion of classical and clinically significant PD can explain many of the well‐characterized pathological and clinical features of the disease and it gives support to the idea that the magic word in PD is variability.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Classical Parkinson disease versus Parkinson complex – Reflections against staging and in favour of heterogeneity</title></titleInfo><titleInfo type="abbreviated"><title>Classical Parkinson disease versus Parkinson complex</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Classical Parkinson disease versus Parkinson complex – Reflections against staging and in favour of heterogeneity</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Linazasoro</namePart><affiliation>Centro De Investigación Parkinson, Policlínica Gipuzkoa, Parque Tecnológico Miramón, San Sebastián (Guipúzcoa), Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2007-07</dateIssued><edition>Received 29 January 2007 Accepted 23 April 2007</edition><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Pathological studies have prompted the idea that Parkinson disease (PD) is a multisystem disorder, which starts far away from the nigrostriatal dopamine system and it goes through a long pre‐clinical period. Evidence from epidemiological research, functional imaging, olfaction and sleep studies provides support to this hypothesis. Accordingly, PD is seen as an homogeneous disease which sequentially affects different neural structures leading to a well‐defined clinical picture. This concept, recently named PD complex, has deep theoretical and practical implications which raise some concerns. This report shows the concept of classical PD as opposed to PD complex. Although the relevance of the central argument concerning the PD complex concept is admitted, it needs to be fully proved before premature conclusions are drawn. In contrast, the notion of classical and clinically significant PD can explain many of the well‐characterized pathological and clinical features of the disease and it gives support to the idea that the magic word in PD is variability.</abstract><subject lang="en"><genre>Keywords</genre><topic>classical Parkinson disease</topic><topic>Parkinson disease</topic><topic>Parkinson disease complex</topic><topic>synucleinopathy</topic><topic>variability</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>14</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>721</start><end>728</end><total>8</total></extent></part></relatedItem><identifier type="istex">BAC0932AE9102A119D5B8708E49FA434BB2D1D3D</identifier><identifier type="DOI">10.1111/j.1468-1331.2007.01853.x</identifier><identifier type="ArticleID">ENE1853</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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